Bioprocess Manufacturing Technician

Company: Hoffmann-La Roche Ltd
Location: Oceanside
Posted on: August 3, 2022

Job Description:

The Position

At Genentech, we are dedicated to pursuing groundbreaking science to discover and develop medicines for people with serious and life-threatening diseases.

As a Bioprocess Manufacturing Technician, you will be responsible for producing medicine in a highly automated and controlled environment. Each product has a specific recipe; you will follow this recipe, along with the standard operating procedures, to operate the production equipment across various areas, including raw material dispensing/aliquoting, cell culture and purification. You will maintain records and follow all the steps necessary to comply with regulatory requirements within a current Good Manufacturing Practices (cGMP) environment.

This is a contract role with the possibility of conversion to a permanent employee position.

There are 3 main production areas within manufacturing:

* Production Services - responsible for weighing and aliquoting of raw materials and small scale solution prep. Also responsible for washing, autoclaving, and preparation of small equipment parts and assemblies.


* Upstream Manufacturing - responsible for cell growth, from inoculation in spinner flasks, managing growth all the way through large scale bioreactors.


* Downstream Manufacturing - responsible for the purification of cellular harvest utilizing chromatography and reformulation techniques, as well as preparation of product for shipping to final fill/finish sites.



As a new member of the team, you'll typically be assigned to one of the three production areas. This will allow you to build capabilities and work on increasingly complex technical assignments, with the potential to rotate into future production areas as you gain experience.

Job Responsibilities

Safety is paramount to both our employees and our patients, and is therefore at the core of all job responsibilities. This includes complying with all safety requirements, cGMP, Standard Operating Procedures (SOP) and manufacturing documentation. You must immediately report any and all safety and environmental incidents, including injuries, illness, near miss & safety suggestions. Additional responsibilities may include:

* Utilizing automated systems to operate, clean and sterilize production equipment


* Operating small-scale cell culture areas and systems by using aseptic techniques, maintaining cell banks; and performing general seed lab operations


* Operating fermenters, centrifuges, other harvest systems and protein purification units


* Operating and cleaning fixed tank and filtration systems


* Operating large scale column chromatography systems


* Preparing solutions required for the production process (media and buffer make-up)


* Cleaning, assembling, and sterilizing equipment for production by operating glass washers and autoclaves


* Executing environmental monitoring throughout the facility



Ideal Candidate Attributes

* You're a quick learner and can receive, digest and interpret instructions with ease


* You're technically and mechanically inclined and can learn new systems and technology quickly


* You find joy in the details and pride yourself in accuracy


* You can work independently but as part of a larger team


* You can demonstrate the ability to independently document and record information


* You showcase good judgement and ability to recognize non-routine problems/deviations and escalate to partner on potential solutions


* You demonstrate increasing technical competency through training and operational procedures of at least one manufacturing department



Shift Details

We have a variety of 12-hour shifts to support our 24x7 facility operations. Staff working over 8 hours in a day will be paid overtime in accordance with local and state laws. In addition, staff working night shifts will be paid a shift differential. While we are occasionally able to accommodate shift requests, candidates with open availability will be given priority consideration as we are not able to guarantee shift placement.

* Frontside Days: Sunday thru Tuesday and alternating Wednesdays 6:00am-7:00pm


* Backside Days: Thursday thru Saturday and alternating Wednesdays 6:00am-7:00pm


* Frontside Nights: Sunday thru Tuesday and alternating Saturdays: 6:00pm-7:00am


* Backside Nights: Wednesday thru Friday and alternating Saturdays: 6:00pm-7:00am


* Frontside Swings: Sunday thru Tuesday and alternating Wednesdays 1:00pm-2:00am


* Backside Swings: Thursday thru Saturday and alternating Wednesdays 1:00pm-2:00am



Additionally, Production Services has a four-day 10-hour shift.

* Frontside Days: Sunday thru Wednesday 8:00am-6:30pm


* Backside Days: Wednesday thru Saturday 8:00am-6:30pm



Physical Requirements

* You'll be on your feet for 8 to 11 hours of the day and will be required to wear Genentech-provided, lab approved steel toe shoes


* Our facility is expansive - you may climb multiple flights of stairs daily


* You should be able to lift up to 25lbs on the rare occasion


* You will work in a clean room environment; you will be required to gown up in the form of hospital scrubs, bunny suits, gloves, hair net, mask, safety glasses, hearing protection


* No makeup or jewelry can be worn when working in the clean room environment


* You may work with hazardous materials and chemicals



Educational Requirements

* High school diploma or equivalent


* Preferred - Degree in Life Sciences/Engineering, Associate's or Biotech certificate from approved program



To complete the initial video interview, please visit:

https://www.sparkhire.com/job/a19599c0-c5fa-4d2a-aa29-039ac147a81f

To learn more about the manufacturing process, please watch this video: https://www.youtube.com/watch?v=sxvJatvqBVE

Please note: We currently do not sponsor work visas for this position or offer relocation assistance.

#LI-AI1, #ptcareers

Who we are

A member of the Roche Group, Genentech has been at the forefront of the biotechnology industry for more than 40 years, using human genetic information to develop novel medicines for serious and life-threatening diseases. Genentech has multiple therapies on the market for cancer & other serious illnesses. Please take this opportunity to learn about Genentech where we believe that our employees are our most important asset & are dedicated to remaining a great place to work.

Unless entitled to a reasonable accommodation under applicable law, employees are required to be fully vaccinated against COVID-19 in accordance with customer requirements, the company's health and safety obligations and/or applicable law or guidelines.

Diversity and Inclusion (D&I) are critical to the success of our company and our impact on society. We believe that by championing diversity of background, thought and experience, we can foster a sense of belonging and provide an environment where every employee feels valued, included, and able to contribute their best for the patients we serve. We're focused on attracting, retaining, developing and advancing our people to their full potential by rewarding bold ways of thinking and integrating inclusive behaviors into every aspect of our work.

Genentech is an equal opportunity employer, and we embrace the increasingly diverse world around us. Genentech prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity or expression, national origin or ancestry, age, disability, marital status and veteran status. For more information about equal employment opportunity, visit our Genentech Careers Homepage.

Keywords: Hoffmann-La Roche Ltd, Oceanside , Bioprocess Manufacturing Technician, Professions , Oceanside, California